PXD058262-2
PXD058262 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Blocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB pathway |
| Description | Clinical trials have demonstrated that CXCR4 antagonists enhance the efficacy of immunotherapy in cancers by reducing regulatory T (Treg) cells, elucidating how certain mechanisms of CXCR4 in affecting Treg cells are essential for developing immunotherapeutic strategies. |
| HostingRepository | iProX |
| AnnounceDate | 2024-11-25 |
| AnnouncementXML | Submission_2025-08-14_23:47:03.217.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Canhui Cao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-11-25 20:19:36 | ID requested | |
| 1 | 2025-08-14 23:46:35 | announced | |
| ⏵ 2 | 2025-08-14 23:47:04 | announced | 2025-08-15: Add info. |
Publication List
| Cao C, Xu M, Peng T, Liu X, Lin S, Xu Y, Chu T, Liu S, Wu P, Hu B, Ding W, Li L, Ma D, Wu P, B signaling axis. Genome Med, 17(1):85(2025) [pubmed] |
Keyword List
| submitter keyword: CXCR4, CD4, Rho-GTPase/NF-κB pathway |
Contact List
| Canhui Cao | |
|---|---|
| contact affiliation | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | canhuicao@tjh.tjmu.edu.cn |
| lab head | |
| Canhui Cao | |
| contact affiliation | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | canhuicao@tjh.tjmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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