PXD058260-1

PXD058260 is an original dataset announced via ProteomeXchange.

Title	Multiomics Profiling Reveals Mitochondrial Metabolic Remodeling During Foam Cell Formation
Description	Macrophages participate in plaque formation and development through the process of foam cell formation, and mitochondria play a crucial role in macrophage phenotype transformation. However, the mitochondrial metabolic characteristics of macrophages during foam cell formation have not been systematically studied. In this work, we investigated the mechanism of mitochondrial metabolic reprogramming during macrophage foam cell formation using proteomics, metabolomics and lipidomics. Multi-omics integrative analysis highlighted key metabolic pathway changes, including the tricarboxylic acid cycle fragmentation, and the recombination of mitochondria protein complexes and mitochondria membrane lipids.
HostingRepository	iProX
AnnounceDate	2024-11-26
AnnouncementXML	Submission_2024-11-25_20:15:39.857.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zengyu Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-25 20:14:14	ID requested
⏵ 1	2024-11-25 20:15:40	announced

Dataset with its publication pending

submitter keyword: foam cell, ox-LDL, THP-1

Liang Qiao
contact affiliation	Fudan University
contact email	liang_qiao@fudan.edu.cn
lab head
Zengyu Wang
contact affiliation	Fudan University
contact email	wangzengyu1999@gmail.com
dataset submitter

iProX dataset URI