PXD058247-1

PXD058247 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Chronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertility disorders
Description	We characterized the sperm proteins recognized by the antibodies in mouse serum and epididymal fluid after immune tolerance disruption by performing mass spectrometry-based label-free quantitative proteomics. For this, we immunoprecipitated sperm cell protein extractions with serum and epididymal fluids from the proximal and distal epididymis of WT and Foxp3-DTR transgenic mice 2 weeks after Treg depletion.
HostingRepository	PRIDE
AnnounceDate	2025-07-10
AnnouncementXML	Submission_2025-07-10_06:44:53.095.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maia Elizagaray
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-25 11:37:02	ID requested
⏵ 1	2025-07-10 06:44:53	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: autoanti-sperm antibodies, serum,Treg depletion, immune tolerance, epididymal fluid

submitter keyword: autoanti-sperm antibodies, serum,Treg depletion, immune tolerance, epididymal fluid

Contact List

Maria Agustina Battistone
contact affiliation	Program in Membrane Biology Nephrology Division Massachusetts General Hospital Harvard Medical School
contact email	mbattistone@mgh.harvard.edu
lab head
Maia Elizagaray
contact affiliation	Massachusetts General Hospital/Harvard Medical School
contact email	melizagaray@mgh.harvard.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD058247
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD058247

PRIDE project URI

Repository Record List

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