PXD058239 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ependymoma instructs cranial haematopoiesis and immunotolerance |
| Description | ZFTA-RELA ependymoma presents a significant clinical challenge due to the lack of effective treatments, driving the need to explore novel immunotherapeutic strategies. Recent studies have identified the skull bone marrow as a source of meningeal immune cells critical for central nervous system (CNS) immunity, yet the role of these cells in childhood CNS tumour surveillance and pathology remains unclear. Here, we demonstrate that intracranial childhood ependymoma tumours harbour a unique myeloid cell population, including hematopoietic stem cells (HSCs) not from the blood, but supplied by adjacent skull bone marrow, ontogenetically distinct from their blood-derived counterparts. Our findings challenge the conventional view of HSCs as passive players in the CNS, revealing that antigen-specific interactions between skull bone marrow-derived HSCs and CD4+ T cells actively promote immunotolerance in childhood brain tumours by enhancing local myelopoiesis and inducing regulatory T cell polarization. This work uncovers a previously unrecognized cellular network linking the skull to brain tumours in children and underscores the therapeutic potential of modulating skull bone marrow haematopoiesis to shift the local immune environment. Targeting this skull-specific immune pathway offers a promising avenue for developing localized immunotherapies to improve treatment outcomes. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-01 |
| AnnouncementXML | Submission_2025-12-01_11:07:30.098.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Valar Nila Roamio Franklin |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-25 07:27:06 | ID requested | |
| ⏵ 1 | 2025-12-01 11:07:30 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Immune Surveillance, Skull Bone Marrow, CSF, Hematopoiesis, Regulatory T cell, Childhood Brain Tumour ,Ependymoma |
Contact List
| Clive D'Santos |
|---|
| contact affiliation | Head of the Department, Proteomics Core Facility |
| contact email | Clivesdsantos@gmail.com |
| lab head | |
| Valar Nila Roamio Franklin |
|---|
| contact affiliation | Principal Scientific Associate |
| contact email | valar.franklin@cruk.cam.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058239
- Label: PRIDE project
- Name: Ependymoma instructs cranial haematopoiesis and immunotolerance
