PXD058193 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Use of the proteomics approach to study endometrial cancer. |
Description | Endometrial cancer (EC) is the second most frequent gynecological malignant tumor in postmenopausal women. Pathogenic mechanisms related to the onset and development of disease are still unknown. In this study, we aimed to characterize the EV proteome by combining Data-Independent Acquisition (DIA) acquisition, in albumin-depleted serum EVs to identify dysregulated proteins and enzymes associated with the disease. A deep proteomics analysis with advanced computational tools allowed us to identify a large number of proteins in serum albumin-depleted extracellular vesicles (EVs) from 10 patients with EC compared to 10 healthy controls. This is the largest number of proteins identified in EC serum EVs. After quantification and statistical analysis, we identified 373 significantly (p < 0.05) dysregulated proteins involved in neutrophil and platelet degranulation pathways. A more detailed bioinformatics analysis revealed 61 dysregulated enzymes related to metabolic and catabolic pathways linked to tumor invasion. Our bioinformatic analysis identified 49 metabolic and catabolic pathways related to tumor growth. MTD project_tag Cancer (B/D-HPP) |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_05:00:51.931.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Michelangelo Aloisio |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-11-23 19:39:44 | ID requested | |
⏵ 1 | 2025-05-07 05:00:53 | announced | |
Publication List
10.3390/biomedicines13010095; |
Kharrat F, Capaci V, Conti A, Golino V, Campiglia P, Balasan N, Aloisio M, Licastro D, Monasta L, Caponneto F, Beltrami AP, Romano F, di Lorenzo G, Ricci G, Ura B, A Pilot Study of Exosome Proteomic Profiling Reveals Dysregulated Metabolic Pathways in Endometrial Cancer. Biomedicines, 13(1):(2025) [pubmed] |
Keyword List
ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
submitter keyword: proteomics |
mass spectrometry |
extracellular vesicles |
Contact List
Blendi Ura |
contact affiliation | Institute for Maternal and Child Health IRCCS “Burlo Garofolo” Department of gynecology 34137 Trieste, Italy |
contact email | blendi.ura@burlo.trieste.it |
lab head | |
Michelangelo Aloisio |
contact affiliation | National Institute of Gastroenterology S. De Bellis, IRCCS Research Hospital, |
contact email | michelangelo.aloisio@irccsdebellis.it |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058193
- Label: PRIDE project
- Name: Use of the proteomics approach to study endometrial cancer.