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PXD058193-1

PXD058193 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleUse of the proteomics approach to study endometrial cancer.
DescriptionEndometrial cancer (EC) is the second most frequent gynecological malignant tumor in postmenopausal women. Pathogenic mechanisms related to the onset and development of disease are still unknown. In this study, we aimed to characterize the EV proteome by combining Data-Independent Acquisition (DIA) acquisition, in albumin-depleted serum EVs to identify dysregulated proteins and enzymes associated with the disease. A deep proteomics analysis with advanced computational tools allowed us to identify a large number of proteins in serum albumin-depleted extracellular vesicles (EVs) from 10 patients with EC compared to 10 healthy controls. This is the largest number of proteins identified in EC serum EVs. After quantification and statistical analysis, we identified 373 significantly (p < 0.05) dysregulated proteins involved in neutrophil and platelet degranulation pathways. A more detailed bioinformatics analysis revealed 61 dysregulated enzymes related to metabolic and catabolic pathways linked to tumor invasion. Our bioinformatic analysis identified 49 metabolic and catabolic pathways related to tumor growth. MTD project_tag Cancer (B/D-HPP)
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-07_05:00:51.931.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichelangelo Aloisio
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-23 19:39:44ID requested
12025-05-07 05:00:53announced
Publication List
10.3390/biomedicines13010095;
Kharrat F, Capaci V, Conti A, Golino V, Campiglia P, Balasan N, Aloisio M, Licastro D, Monasta L, Caponneto F, Beltrami AP, Romano F, di Lorenzo G, Ricci G, Ura B, A Pilot Study of Exosome Proteomic Profiling Reveals Dysregulated Metabolic Pathways in Endometrial Cancer. Biomedicines, 13(1):(2025) [pubmed]
Keyword List
ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
submitter keyword: proteomics
mass spectrometry
extracellular vesicles
Contact List
Blendi Ura
contact affiliationInstitute for Maternal and Child Health IRCCS “Burlo Garofolo” Department of gynecology 34137 Trieste, Italy
contact emailblendi.ura@burlo.trieste.it
lab head
Michelangelo Aloisio
contact affiliationNational Institute of Gastroenterology S. De Bellis, IRCCS Research Hospital,
contact emailmichelangelo.aloisio@irccsdebellis.it
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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