PXD058115-1

PXD058115 is an original dataset announced via ProteomeXchange.

Title	Serum proteomic analysis unravels novel biomarkers for amyotrophic lateral sclerosis
Description	Amyotrophic lateral sclerosis (ALS), characterized by its insidious onset and progressive deterioration, poses a significant diagnostic challenge due to the lack of biomarkers in clinical practice. This study aims to unravel the serum biomarkers associated with ALS. We conducted a proteomic analysis of serum samples from a training group comprising 45 ALS patients and 45 healthy controls using magnetic bead-based immobilized metal ion affinity chromatography (MB-IMAC) and MALDI-TOF-MS technology. The differentially expressed peaks were screened using ClinProTools software and subsequently identified by LC-MS/MS.
HostingRepository	iProX
AnnounceDate	2024-11-20
AnnouncementXML	Submission_2024-11-20_21:32:04.374.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bingju Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	matrix-assisted laser desorption ionization

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-20 21:25:44	ID requested
⏵ 1	2024-11-20 21:32:04	announced

Dataset with its publication pending

submitter keyword: Amyotrophic lateral sclerosis, Serum, Proteomic, Biomarker, Mass spectrometry

Chen Huang
contact affiliation	Xi'an Jiaotong University Health Science Center
contact email	hchen@mail.xjtu.edu.cn
lab head
Bingju Wang
contact affiliation	Xi'an Jiaotong University Health Science Center
contact email	wangbingju2021@163.com
dataset submitter

iProX dataset URI