PXD058077-1
PXD058077 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease |
| Description | Anti-synthetase syndrome (ASS), a subtype of idiopathic inflammatory myopathy (IMM), is characterized by distinctive skin rashes, proximal muscle weakness, and interstitial lung disease (ILD). The etiology of ASS remains largely unknown, and patients endure a poor quality of life and are prone to pulmonary infection. Recent studies have highlighted the potential role of aberrant glycosylation of immunoglobulin G (IgG) in the development of autoimmune diseases. However, the specific N-glycosylation patterns of IgG in ASS have not yet been fully elucidated. In this study, we employed GlycoQuant, a method for intact glycopeptide analysis, to investigate the intact N-glycopeptides of IgG from 30 ASS patients and 30 healthy controls (HC). Our analysis revealed 13 differentially expressed intact N-glycopeptides in ASS. Furthermore, we observed a significant increase in fucose alongside a marked decrease in N-acetylneuraminic acid levels among ASS patients. Crucially, alterations in IgG N-glycosylation correlated with the disease severity. In conclusion, this study provides a thorough overview of IgG N-glycosylation patterns in ASS, laying a solid foundation for future research in this area. |
| HostingRepository | iProX |
| AnnounceDate | 2024-11-20 |
| AnnouncementXML | Submission_2024-11-19_23:22:33.774.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yong Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | deaminated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-11-19 23:22:17 | ID requested | |
| ⏵ 1 | 2024-11-19 23:22:34 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Anti-synthetase syndrome (ASS), N-glycosylation, Glycopeptide, Immunoglobulin G (IgG) |
Contact List
| Yong Zhang | |
|---|---|
| contact affiliation | West China Hospital, Sichuan University |
| contact email | nankai1989@foxmail.com |
| lab head | |
| Yong Zhang | |
| contact affiliation | West China Hospital, Sichuan University |
| contact email | nankai1989@foxmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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