PXD058068-1

PXD058068 is an original dataset announced via ProteomeXchange.

Title	Delayed crosstalk between astrocytes and neurons leads to depressive-like behaviors
Description	Neural functions and circuit establishment are characterized by intricate crosstalk among multiple cell types during critical periods. Impeding or delaying the crosstalk results in abnormal neural functions and neurodevelopmental disorders. However, the lack of robust mouse models to study the crosstalk between astrocytes and neurons thus renders unclear the implications of impeding such interactions. Here we found that Egfr knockout led to the absence of astrocytes during the critical period of neuronal maturation, with recovery observed in adult mice, providing an exceptional opportunity to investigate the consequences of delaying crosstalk between astrocytes and neurons. We show that, in the absence of Egfr, glial progenitor cells are unable to migrate outwardly, exhibiting a rounded and smooth morphology. This phenomenon arises as a direct consequence of the impaired Egfr-pERK-Epb41l2 signaling axis, leading to delayed communication between astrocytes and neurons. This delay results in reduced neuronal dendritic complexity and decreased neuronal excitability (due to damage to the Sema6a-Plxna2/4 receptor pair between astrocytes and neurons during the critical period), ultimately leading to the manifestation of depressive-like behaviors in adult mice.
HostingRepository	iProX
AnnounceDate	2024-11-19
AnnouncementXML	Submission_2025-01-01_19:47:35.031.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xin Jiang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-19 21:33:22	ID requested
⏵ 1	2025-01-01 19:47:35	announced

Dataset with its publication pending

submitter keyword: crosstalk, astrocytes, neurons,EGFR,EPB,SEMA6A

Zhengang Yang
contact affiliation	Institutes of Brain Science
contact email	21111520014@m.fudan.edu.cn
lab head
Xin Jiang
contact affiliation	Institutes of Brain Science
contact email	21111520014@m.fudan.edu.cn
dataset submitter

iProX dataset URI