PXD058061 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Choline kinase promotes glycolysis and tumor growth by phosphorylating and activating enolase 1 |
| Description | Tumor cells exhibit aberrantly upregulated glycolysis, in which glycolytic enzyme enolase 1 (ENO1) plays a critical role. However, how ENO1 activity is dynamically regulated in tumor cells remains elusive. Here, we demonstrate that hypoxic stimulation promotes the binding of p38 MAP kinase to choline kinase α (CHKα). p38 phosphorylates CHKα, subsequently leading to CHKα to interact with ENO1. Importantly, CHKα functions as a protein kinase and phosphorylates ENO1 thereby enhancing the metabolic activity of ENO1 to increase glycolysis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-05 |
| AnnouncementXML | Submission_2026-09-05_07:09:53.971.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD058061 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Hongfei Jiang |
| SpeciesList | scientific name: Acyrthosiphon pisum (Pea aphid); NCBI TaxID: NEWT:7029; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-19 20:41:23 | ID requested | |
| ⏵ 1 | 2026-09-05 07:09:54 | announced | |
Publication List
Keyword List
Contact List
| Zhimin Lu |
|---|
| contact affiliation | Zhejiang University |
| contact email | zhiminlu@zju.edu.cn |
| lab head | |
| Hongfei Jiang |
|---|
| contact affiliation | Guangxi University |
| contact email | 1209890391@qq.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD058061 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058061
- Label: PRIDE project
- Name: Choline kinase promotes glycolysis and tumor growth by phosphorylating and activating enolase 1
