PXD058049 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Revealing Melanoma Cell Proteome Transformations with Silver Nanoparticles: An Innovative Comparative Study |
| Description | Addressing the challenges of melanoma, including its aggressive nature and treatment resistance. This study explores the application of silver nanoparticles (AgNPs) synthesized via conventional and green methods. By examining proteomic changes in A375 melanoma cells, we identify key disruptions in cell viability and gene activity. The DIA MS/SWATH MS analysis generates a set of differentially expressed proteins with respect to AgNPs. This allows us to identify new potential regulatory mechanisms and molecular pathways. AgNP exposure leads to oxidative stress, mitochondrial dysfunction, and activation of apoptosis pathways, revealing the potential of AgNPs in melanoma treatment. This comprehensive analysis highlights the promise of eco-friendly nanoparticle synthesis in developing effective anti-cancer therapies. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-05-07 |
| AnnouncementXML | Submission_2025-05-07_06:26:00.698.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jakub Faktor |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-19 07:41:29 | ID requested | |
| ⏵ 1 | 2025-05-07 06:26:01 | announced | |
Publication List
| Martano S, Faktor J, Kote S, Cascione M, Di Corato R, Faktorova D, Semeraro P, Rizzello L, Leporatti S, Rinaldi R, De Matteis V, DIA/SWATH-Mass Spectrometry Revealing Melanoma Cell Proteome Transformations with Silver Nanoparticles: An Innovative Comparative Study. Int J Mol Sci, 26(5):(2025) [pubmed] |
| 10.3390/ijms26052029; |
Keyword List
| submitter keyword: Melanoma, Silver nanoparticles (AgNPs), DIA MS, Nanomedicine, SWATH MS, Proteomics,Green Nanoparticles, Anti-cancer |
Contact List
| Sachin Kote |
|---|
| contact affiliation | International Centre for Cancer Vaccine Science, University of Gdansk, Kladki 24, 80-822 Gdansk, Poland |
| contact email | sachin.kote@ug.edu.pl |
| lab head | |
| Jakub Faktor |
|---|
| contact affiliation | University of Gdansk
Kladki 24
Gdansk |
| contact email | jakub.faktor@ug.edu.pl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058049 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058049
- Label: PRIDE project
- Name: Revealing Melanoma Cell Proteome Transformations with Silver Nanoparticles: An Innovative Comparative Study
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