PXD058047-1

PXD058047 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Whole proteome experiment to validate treatment conditions in SJSA-1 cells
Description	Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. The selectivity of this molecule is poorly understood. So we synthesised and validated two photoactivatable clickable probes of Navtemadlin. This data shows the validation of treatment conditions through whole proteome proteomics experiments in order to ensure that the expression of key proteins such as MDM2 is uniform across conditions.
HostingRepository	PRIDE
AnnounceDate	2025-04-28
AnnouncementXML	Submission_2025-04-28_07:17:05.046.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Amrita Date
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF HT

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-19 07:31:30	ID requested
⏵ 1	2025-04-28 07:17:05	announced

Publication List

Date A, Wall A, Zhang P, Houghton JW, Lu J, Thomas AM, Kova, č, i, č T, Wilson AJ, Tate EW, Barnard A, Affinity-based protein profiling of MDM2 inhibitor Navtemadlin. Chem Sci, 16(16):6886-6894(2025) [pubmed]
10.1039/d5sc00120j;

Date A, Wall A, Zhang P, Houghton JW, Lu J, Thomas AM, Kova, č, i, č T, Wilson AJ, Tate EW, Barnard A, Affinity-based protein profiling of MDM2 inhibitor Navtemadlin. Chem Sci, 16(16):6886-6894(2025) [pubmed]

10.1039/d5sc00120j;

Keyword List

submitter keyword: SJSA-1, whole proteome, Navtemadlin

submitter keyword: SJSA-1, whole proteome, Navtemadlin

Contact List

Anna Barnadr
contact affiliation	Imperial College London
contact email	a.barnard@imperial.ac.uk
lab head
Amrita Date
contact affiliation	Imperial College London
contact email	a.date19@imperial.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD058047
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD058047

PRIDE project URI

Repository Record List

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