PXD058028-1

PXD058028 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Therapy-induced senescence is a drug resistance mechanism in breast cancer
Description	Here, we investigate therapy-induced senescence (TIS) as a reversible mechanism of drug resistance in breast cancer cells. High-dose doxorubicin treatment was used to induce TIS in four distinct breast cancer cell lines and the drug resistance/sensitivity pattern of parental and TIS cells were investigated using a panel of FDA-approved anticancer molecules. Proteome analysis confirmed the presence of the Senescence-Associated Secretory Phenotype (SASP), altered spliceosomal activity and proteins with significant role in immune evasion.
HostingRepository	jPOST
AnnounceDate	2024-11-19
AnnouncementXML	Submission_2024-11-19_09:43:11.503.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zoltan Szabo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; 2-pyrrolidone-5-carboxylic acid (Gln); CAMthiopropanoyl; L-methionine sulfoxide; deamidated L-asparagine
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-19 01:00:22	ID requested
⏵ 1	2024-11-19 09:43:11	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: data indepenent analysis, cell surface, cancer

submitter keyword: data indepenent analysis, cell surface, cancer

Contact List

Zoltan Szabo
lab head
Zoltan Szabo
contact affiliation	University of Szeged
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003475/