PXD058010-1

PXD058010 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	TYMS expression regulates AMPK-mTOR signaling in pancreatic neuroendocrine tumors
Description	AMPK serves as a regulator of metabolic homeostasis to conserve energy in tumor cells by inhibiting ATP-anabolic processes and promoting ATP-generating pathways. When activated, AMPK reprograms cellular metabolism and imposes growth checkpoints, particularly through inhibition of the mTOR signaling pathway. Since mTOR is activated in a subset of PanNET patients, the AMPK-mTOR signaling axis is a crucial target to evaluate the risk for chemotherapy drugs resistance and overall prognosis in these patients. We now report that elevated TYMS levels downregulates AMPK signaling and activates mTOR signaling in PanNET tumor cells. These data suggest a new role for TYMS inhibition to modulate the AMPK-mTOR signaling axis and impact the efficacy of current mTOR inhibitory agents in the management of patients with advanced PanNET.
HostingRepository	MassIVE
AnnounceDate	2025-09-25
AnnouncementXML	Submission_2025-09-25_06:32:14.756.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jin Koh
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	TMTpro
Instrument	Orbitrap Fusion ETD

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-18 14:07:15	ID requested
⏵ 1	2025-09-25 06:32:15	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: TYMS, AMPK-mTOR signaling, pancreatic neuroendocrine tumors, TMT, DatasetType:Proteomics

submitter keyword: TYMS, AMPK-mTOR signaling, pancreatic neuroendocrine tumors, TMT, DatasetType:Proteomics

Contact List

Maria Zajac-Kaye
contact affiliation	University of Florida
contact email	mzajackaye@ufl.edu
lab head
Jin Koh
contact affiliation	University of Florida
contact email	jinkoh@ufl.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096459/