PXD057931-1

PXD057931 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of moncytes treated with the HDAC6 inhibitor ITF3756
Description	Tumor immunotherapy has revolutionized cancer treatment, particularly through the use of immune checkpoint inhibitors targeting the PD-L1/PD-1 axis. While PD-L1 expression on tumor cells has been established as a predictive biomarker for therapeutic response, emerging evidence highlights the significance of PD-L1 expression on myeloid cells in the periphery and in the tumor microenvironment (TME). This study investigates the effects of the selective HDAC6 inhibitor ITF3756 on PD-L1 expression and on the immune functionality of monocytes stimulated with the pro-inflammatory cytokine TNF-α.
HostingRepository	PRIDE
AnnounceDate	2025-05-09
AnnouncementXML	Submission_2025-05-09_01:55:59.146.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roberta Noberini
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-15 05:33:22	ID requested
⏵ 1	2025-05-09 01:55:59	announced

Dataset with its publication pending

submitter keyword: deacetylase inhibitors, checkpoint inhibitors, monocytes

Tiziana Bonaldi
contact affiliation	European Institute of Oncology, Milan, Italy
contact email	tiziana.bonaldi@ieo.it
lab head
Roberta Noberini
contact affiliation	Istituto Europeo di Oncologia
contact email	roberta.noberini@ieo.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD057931

PRIDE project URI

• PRIDE
  1. PXD057931
     1. Label: PRIDE project
     2. Name: Proteomics analysis of moncytes treated with the HDAC6 inhibitor ITF3756