PXD057882-2
PXD057882 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comprehensive N-Glycomics Profiling of Urinary Extracellular Vesicles Identifies a Novel Biomarker Panel for Diagnosis of Bladder Cancer |
| Description | Bladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges.Urinary extracellular vesicles (EVs) is a particularly promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine and bladder. We investigate biomarkers for bladder cancer diagnosis based on an N-glycomics study involving the clinical cohort of 333 individuals. Finally, eight N-glycans were screened out to construct a diagnostic model, able to well differentiate bladder cancer from healthy individuals.To further understand the functions and potential roles of urinary EVs, we conducted N-glycoproteomic analysis of urinary EVs from the BC, UB, UM, and HC groups to explore the nature of glycoproteins carrying cancer-associated N-glycan signatures in EVs. |
| HostingRepository | iProX |
| AnnounceDate | 2024-11-14 |
| AnnouncementXML | Submission_2025-08-20_19:15:33.152.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yang Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-11-13 23:28:44 | ID requested | |
| 1 | 2025-02-26 17:58:07 | announced | |
| ⏵ 2 | 2025-08-20 19:15:33 | announced | 2025-08-21: Add info. |
Publication List
| Li Y, Fu B, Wang M, Chen W, Fan J, Li Y, Liu X, Wang J, Zhang Z, Lu H, Zhang Y, Urinary extracellular vesicle N-glycomics identifies diagnostic glycosignatures for bladder cancer. Nat Commun, 16(1):2292(2025) [pubmed] |
Keyword List
| submitter keyword: urinary extracellular vesicles;bladder cancer;N-glycosylation;biomarker |
Contact List
| Haojie Lu | |
|---|---|
| contact affiliation | Fudan University |
| contact email | luhaojie@fudan.edu.cn |
| lab head | |
| Yang Li | |
| contact affiliation | Fudan University |
| contact email | 251298630@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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