PXD057861-1

PXD057861 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Genetic context modulates aging and degeneration in the murine retina
Description	This is the proteomics component of a multi-omics analysis of the aging murine retina. Age is a critical risk factor for vision-threatening retinopathies. Susceptibility to age-related retinal neurodegeneration is genetically influenced, however, no studies have addressed molecular retinal aging signatures across genetically diverse populations. Here, we profile retinal proteomics in an array of genetically diverse mice with age. Proteomics were employed to profile retinal aging signatures in C57BL/6J (B6), 129S1/SvImJ, NZO/HlLtJ (NZO), WSB/EiJ (WSB), CAST/EiJ, PWK/PhJ, NOD/ShiLtJ, A/J, and BALB/cJ mouse strains at 4, 12, and 18M. These data were collated into a publicly available resource.
HostingRepository	PRIDE
AnnounceDate	2025-01-23
AnnouncementXML	Submission_2025-01-23_06:35:48.941.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD057861
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Michael MacLean
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-13 13:06:53	ID requested
⏵ 1	2025-01-23 06:35:49	announced

Publication List

10.6019/PXD057861;
10.1186/s13024-025-00800-9;
Marola OJ, MacLean M, Cossette TL, Diemler CA, Hewes AA, Reagan AM, Kanyinda JN, Skelly DA, Howell GR, Genetic context modulates aging and degeneration in the murine retina. Mol Neurodegener, 20(1):8(2025) [pubmed]

10.6019/PXD057861;

10.1186/s13024-025-00800-9;

Marola OJ, MacLean M, Cossette TL, Diemler CA, Hewes AA, Reagan AM, Kanyinda JN, Skelly DA, Howell GR, Genetic context modulates aging and degeneration in the murine retina. Mol Neurodegener, 20(1):8(2025) [pubmed]

Keyword List

submitter keyword: genetic diversity, proteomics, retinal vascular disease, TMT,WSB, retinitis pigmentosa, NZO, aging, retina, diabetic retinopathy, LC-MS/MS

submitter keyword: genetic diversity, proteomics, retinal vascular disease, TMT,WSB, retinitis pigmentosa, NZO, aging, retina, diabetic retinopathy, LC-MS/MS

Contact List

Gareth Howell
contact affiliation	Professor, The Jackson Laboratory, Bar Harbor, ME 04609 USA
contact email	gareth.howell@jax.org
lab head
Michael MacLean
contact affiliation	The Jackson Laboratory
contact email	michael.maclean@jax.org
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD057861

PRIDE project URI

Repository Record List

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