PXD057819-1

PXD057819 is an original dataset announced via ProteomeXchange.

Title	Inhibition Peroxiredoxin-2 by capsaicin ameliorates rheumatoid arthritis via ROS-mediated apoptosis in fibroblast-like synoviocytes
Description	In this project we discovered that CAP not only reduces joint swelling in arthritic model mice but also exhibits anti-inflammatory and antiproliferative effects on fibroblast-like synoviocytes (FLS). By synthesizing alkyne-tagged CAP probes and employing activity-based protein profiling (ABPP), we identified and confirmed that CAP binds to PRDX2, inhibiting its antioxidant function and thereby inducing cellular oxidative stress and apoptosis, which contribute to its anti-arthritic effects. Furthermore, we found that the PRDX2 inhibitor, Conoidin A (ConA), produces similar effects. The results indicate that PRDX2 serve as a potential target for capsaicin to therapeutic intervention in rheumatoid arthritis.
HostingRepository	iProX
AnnounceDate	2024-11-12
AnnouncementXML	Submission_2025-11-03_01:07:14.029.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Junhui Chen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-12 20:05:49	ID requested
⏵ 1	2025-11-03 01:07:15	announced

He H, Hao M, Luo P, Chen J, An Y, Huang J, He R, Du Q, Zhang Q, Wang J, Inhibition Peroxiredoxin-2 by Capsaicin Ameliorates Rheumatoid Arthritis via ROS-Mediated Apoptosis in Fibroblast-Like Synoviocytes. MedComm (2020), 6(6):e70209(2025) [pubmed]

submitter keyword: Rheumatoid arthritis, Antioxidant, Capsaicin, Peroxiredoxin-2

Jigang Wang
contact affiliation	Shenzhen People's Hospital
contact email	jgwang@icmm.ac.cn
lab head
Junhui Chen
contact affiliation	Shenzhen People's Hospital
contact email	chenjhbio@163.com
dataset submitter

iProX dataset URI