PXD057713-1

PXD057713 is an original dataset announced via ProteomeXchange.

Title	Oral delivery of a cholera toxin-binding protein protects against diarrhoea in experimental cholera
Description	Oral cholera vaccines (OCVs) have become important components of strategies for cholera control, but the demand for OCVs has outstripped the supply2–4. There is a need for new cholera control measures for the one billion people living in cholera endemic regions5. The use of orally delivered single-domain antibodies has been proposed as a potential approach for the control of gastrointestinal pathogens6. Here, we describe the development of an orally deliverable bivalent VHH construct (BL3.2) that binds to the B-subunit of cholera toxin (CTXB). The epitope of CTXB for binding molecule BL3.2 was mapped by Hydrogen Deuterium Exchange HDX
HostingRepository	PRIDE
AnnounceDate	2025-02-24
AnnouncementXML	Submission_2025-02-24_05:37:42.871.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dario Segura-Pena
SpeciesList	scientific name: Vibrio cholerae H1; NCBI TaxID: 1093790;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-10 15:32:40	ID requested
⏵ 1	2025-02-24 05:37:43	announced

Dataset with its publication pending

ProteomeXchange project tag: Antibodies (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: CTXB,HDX

Nikolina Sekulic
contact affiliation	Institute for Basic Medical Sciences Department of Molecular Medicine Faculty of Medicine, University of Oslo
contact email	nikolina.sekulic@biotek.uio.no
lab head
Dario Segura-Pena
contact affiliation	Researcher
contact email	dario.segura-pena@ncmm.uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD057713

PRIDE project URI

• PRIDE
  1. PXD057713
     1. Label: PRIDE project
     2. Name: Oral delivery of a cholera toxin-binding protein protects against diarrhoea in experimental cholera