PXD057706-1

PXD057706 is an original dataset announced via ProteomeXchange.

Title	Cysteine profiling by CL26-alkyne to investigate protein targets of CL26 in Huh7 cells
Description	We have identified CL26 as a covalent inhibitor against AGPAT4, an aberrant protein complicated in hepatocellular carcinoma (HCC). CL26 treatment reversed HCC stemness and resistance to the first-line medication sorafenib. This experiment was conducted to investigate the protein targets of CL26 in Huh7 cells.
HostingRepository	PRIDE
AnnounceDate	2025-07-21
AnnouncementXML	Submission_2025-07-20_21:18:47.776.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tin Yan Koo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-10 08:06:57	ID requested
⏵ 1	2025-07-20 21:18:48	announced

Dataset with its publication pending

submitter keyword: Human, LC-MSMS, Liver

CHUNG, Clive Yik Sham
contact affiliation	School of Biomedical Sciences and Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
contact email	cyschung@hku.hk
lab head
Tin Yan Koo
contact affiliation	The University of Hong Kong
contact email	u3548650@connect.hku.hk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD057706

PRIDE project URI

• PRIDE
  1. PXD057706
     1. Label: PRIDE project
     2. Name: Cysteine profiling by CL26-alkyne to investigate protein targets of CL26 in Huh7 cells