PXD057698 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | tRF-22 RNA pulldown and Co-IP followed by LC-MS/MS in human cell samples |
| Description | tRNA-derived fragments (tRFs) play a crucial role in tumor progression. However, whether and how tRFs regulate the immune response in esophageal squamous cell carcinoma (ESCC) and their potential clinical applications remain unclear. tRF-22 enhances myeloid-derived suppressor cells (MDSCs) infiltration via a tRF-22–hnRNPAB–TGFβ2 axis, which in turn leads to the suppression of CD8+ T cells. Targeting tRF-22 or TGFβ2 reactivates antitumor immunity and synergistically enhances the effectiveness of anti-PD1 therapy in ESCC. Patients with lower tRF-22 levels exhibit better responses to immunotherapy and longer progression-free survival in our ESCC-ICB cohort. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-12 |
| AnnouncementXML | Submission_2026-01-11_16:09:08.530.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xin Qin |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-09 05:25:40 | ID requested | |
| ⏵ 1 | 2026-01-11 16:09:09 | announced | |
Publication List
| 10.1002/advs.202505806; |
| Pan L, Qin X, Gong L, Liu H, Cheng B, Wang J, Hu Y, Zeng L, Wang Y, Song Q, Cheng Y, tRNA-Derived Fragment tRF-22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma. Adv Sci (Weinh), 13(1):e05806(2026) [pubmed] |
Keyword List
| submitter keyword: Human, Cell, tRF-22, ESCC, LC-MS/MS |
Contact List
| Ling Pan |
|---|
| contact affiliation | Qilu Hospital of Shandong University |
| contact email | panling_1206@163.com |
| lab head | |
| Xin Qin |
|---|
| contact affiliation | Qilu Hospital of Shandong University |
| contact email | qinxinsdu2018@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057698
- Label: PRIDE project
- Name: tRF-22 RNA pulldown and Co-IP followed by LC-MS/MS in human cell samples
