PXD057691-1

PXD057691 is an original dataset announced via ProteomeXchange.

Title	MFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
Description	To identify which E3 ligases ubiquitinate PD-L1, we overexpressed PD-L1-Flag in HEK293 cells and used anti-Flag magnetic beads to pull down PD-L1 from cell lysates. The interacting proteins were then analyzed by mass spectrometry, revealing that three E3 ligases interact with PD-L1.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_04:27:50.283.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD057691
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	peihan wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-08 20:53:41	ID requested
⏵ 1	2025-05-07 04:27:51	announced

10.6019/PXD057691;

10.1016/j.xcrm.2024.101922;

Wang W, Chen J, Wang S, Sun X, Yang J, Yu P, Hu G, Wang J, Zhang J, Qiao S, Wang J, Zhang G, He Y, Feng H, Cai Z, MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1. Cell Rep Med, 6(2):101922(2025) [pubmed]

submitter keyword: anti-PD-1-therapy resistance, UBE4A,Extracellular vesicles, MFGE8, PD-L1

Zhijian Cai
contact affiliation	Institute of Immunology and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
contact email	caizj@zju.edu.cn
lab head
peihan wu
contact affiliation	Westlake University
contact email	wupeihan@westlake.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD057691

PRIDE project URI

• PRIDE
  1. PXD057691
     1. Label: PRIDE project
     2. Name: MFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1