PXD057661-1

PXD057661 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of serum in patients with pancreatic cystic lesions identifies novel biomarkers of pancreatic cancer risk
Description	Pancreatic Cancer (PC) has the worst 5-year survival rate of any cancer as of 2024, at just 13%. The late-stage diagnosis of these patients limits their treatment options, further compounding the problem. Early detection of PC, therefore, is the primary concern of most PC research, as it has the potential to make a substantial difference to the treatment and survival of these patients. Pancreatic cystic lesions (PCLs) are fluid-filled sacs, on or inside the pancreas, that have the potential to become premalignant. While some PCLs are completely benign, others have been shown to have malignant potential and could therefore play a role in the progression to PC. Using the 2018 European evidence-based guidelines for pancreatic cystic neoplasms, patients were classified as being either at a low- or high-risk of PC development. In this study, we profile the proteome of serum from low-risk (n=45) and high-risk (n=23) patients with PCLs and identify differentially expressed proteins between these two risk classifications. We show that these serum-based differentially expressed proteins have potential utility as biomarkers of risk stratification in this setting.
HostingRepository	PRIDE
AnnounceDate	2025-01-17
AnnouncementXML	Submission_2025-01-17_06:46:03.137.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Kane
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-08 03:54:17	ID requested
⏵ 1	2025-01-17 06:46:03	announced

Kane LE, Mellotte GS, Mylod E, Dowling P, Marcone S, Scaife C, Kenny EM, Henry M, Meleady P, Ridgway PF, MacCarthy F, Conlon KC, Ryan BM, Maher SG, Multi-omic biomarker panel in pancreatic cyst fluid and serum predicts patients at a high risk of pancreatic cancer development. Sci Rep, 15(1):129(2025) [pubmed]

10.1038/s41598-024-83742-4;

submitter keyword: Human, Pancreatic, Serum, LC-MS, Risk, Pancreatic Cancer, Cystic Lesions, Proteomics, Biomarkers

Stephen Maher
contact affiliation	Professor in Translational Oncology Director of Postgraduate Teaching and Learning, School of Medicine Principal Investigator, Cancer Chemoradiation Research Group Department of Surgery, Trinity Translational Medicine Institute Trinity College Dublin, St. James’s Hospital, Dublin
contact email	maherst@tcd.ie
lab head
Laura Kane
contact affiliation	Trinity College Dublin
contact email	lakane@tcd.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD057661

PRIDE project URI

• PRIDE
  1. PXD057661
     1. Label: PRIDE project
     2. Name: Proteomic profiling of serum in patients with pancreatic cystic lesions identifies novel biomarkers of pancreatic cancer risk