PXD057645 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Role of PRMT5 in DNA damage response |
| Description | Protein arginine methyltransferase (PRMT5) has emerged as a crucial symmetric dimethylating enzyme involved in the methylation of a myriad of substrates critical for epigenetic regulation, DNA damage signalling, RNA splicing, and cell fate decision. Here we have uploaded the PRMT5 interactome with the nuclear and mitochondrial proteins. The Arginine methylation of rge proteins were evaluated for biological Function. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-16 |
| AnnouncementXML | Submission_2026-03-16_08:38:29.291.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Benu Brata Das |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-07 22:11:45 | ID requested | |
| ⏵ 1 | 2026-03-16 08:38:30 | announced | |
Publication List
| Bhattacharjee S, Das S, Chowdhury B, Das BB, PRMT5 in mitochondria regulates mtDNA stability through TFAM arginine methylation. Nat Commun, ():(2026) [pubmed] |
| 10.1038/s41467-026-69676-7; |
Keyword List
| submitter keyword: mitochondrial homeostasis, post translational modification, PRMT5, mitochondrial biogenesis,TFAM, mtDNA damage |
Contact List
| Benu Brata |
|---|
| contact affiliation | Professor Wellcome-Trust/ DBT India alliance fellow Head, Laboratory of Molecular Biology School of Biological Sciences Indian Association For The Cultivation Of Science |
| contact email | pcbbd@iacs.res.in |
| lab head | |
| Benu Brata Das |
|---|
| contact affiliation | Laboratory of Molecular Biology, School of Biological Sciences, Indian Association for the Cultivation of Science, 2A & B, Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, India. Tel: +91 33 2473 4971 |
| contact email | pcspc@iacs.res.in |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD057645 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057645
- Label: PRIDE project
- Name: Role of PRMT5 in DNA damage response
