PXD057499 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Synaptic phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein pathology |
| Description | Lewy body inclusions enriched with aggregated forms of the presynaptic protein alpha-synuclein (aSyn) are a hallmark of synucleinopathy diseases such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB). To model this pathology, Sprague-Dawley rats were injected in the striatum with preformed fibrils (PFFs) prepared from mouse aSyn to induce the aggregation of the endogenous mouse protein. Monomeric aSyn was injected as a control. Aggregated aSyn was detected via immunohistochemical staining in the sensorimotor cortex at 1- and 3-months post-injection in PFF-injected rats, but not monomer-injected animals. Global proteomics analysis was carried out on homogenates from the sensorimotor cortex of rats inoculated with PFFs or monomer, 3 months post-injection, and the data are presented here. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-26 |
| AnnouncementXML | Submission_2026-08-25_20:48:30.884.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Rodrigo Mohallem |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | acetylated residue; monohydroxylated residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-04 11:32:39 | ID requested | |
| ⏵ 1 | 2026-08-25 20:48:31 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Parkinson's Disease, dementia with Lewy body, global proteomics,Cortex |
Contact List
| Jean-Christophe Rochet |
|---|
| contact affiliation | Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana 47907, United States |
| contact email | jrochet@purdue.edu |
| lab head | |
| Rodrigo Mohallem |
|---|
| contact affiliation | Purdue University |
| contact email | ferreir@purdue.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD057499 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057499
- Label: PRIDE project
- Name: Synaptic phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein pathology
