PXD057486-1

PXD057486 is an original dataset announced via ProteomeXchange.

Title	Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor
Description	Hypoxia-inducible factor-prolyl hydroxylase (HIF-PHD) inhibitors have been approved for treating renal anemia, yet have failed clinical testing for inflammatory bowel disease (IBD) due to lack of efficacy. We use a multimodel multimodal generative AI platform to design an orally gut-restricted selective PHD1/2 inhibitor, which exhibits favorable safety and pharmacokinetic profiles in preclinical studies. ISM012-042 restores intestinal barrier function and alleviates gut inflammation in multiple experimental colitis models.
HostingRepository	PRIDE
AnnounceDate	2024-12-12
AnnouncementXML	Submission_2024-12-11_17:49:48.288.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chenxi Xu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-04 05:37:48	ID requested
⏵ 1	2024-12-11 17:49:48	announced

10.1038/S41587-024-02503-W;

submitter keyword: Mouse Colon PHDi

Yanyun Fu
contact affiliation	Insilico Medicine
contact email	yanyun.fu@insilico.ai
lab head
Chenxi Xu
contact affiliation	Insilico Medicine
contact email	chenxi.xu@insilico.ai
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD057486

PRIDE project URI

• PRIDE
  1. PXD057486
     1. Label: PRIDE project
     2. Name: Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor