PXD057478-1

PXD057478 is an original dataset announced via ProteomeXchange.

Title	Direct circMAN1A2(2,3,4,5)-CENPB mRNA interaction regulates cell proliferation and cancer progression
Description	Alternative circularization (AC) results in multiple circular transcripts from a single gene locus. Here, we profile the landscape of AC across multiple cell lines and colorectal cancer (CRC) tissues, and identify alternatively-circularized circMAN1A2(2,3,4,5) as a universally and predominantly expressed circular RNA, playing a role in cell proliferation and CRC progression. Mechanistically, circMAN1A2(2,3,4,5) enhances IGF2BP2-mediated Centromere Protein B (CENPB) mRNA stability through a direct interaction with CENPB mRNA via its characteristic back-splicing junction site. Both shRNAs and locked nucleic acids specifically targeting circMAN1A2(2,3,4,5) inhibit CRC progression, suggesting a potential therapeutic target for CRC treatment.
HostingRepository	iProX
AnnounceDate	2024-11-01
AnnouncementXML	Submission_2025-07-27_21:06:02.856.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guohua Yuan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-03 23:52:38	ID requested
⏵ 1	2025-07-27 21:06:03	announced

Dataset with its publication pending

submitter keyword: circMAN1A2, RNA interaction, IGF2BP2

Yang Li
contact affiliation	Fudan University
contact email	liyang_fudan@fudan.edu.cn
lab head
Guohua Yuan
contact affiliation	Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
contact email	yuanguohua2020@sibs.ac.cn
dataset submitter

iProX dataset URI