PXD057450-1

PXD057450 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Integrated analysis of the anoikis-related signature identifies RAC3 as a novel therapeutic target in hepatocellular carcinoma
Description	Introduction: Anoikis is a form of programmed cell death. Anoikis resistance in hepatocellular carcinoma (HCC) promotes cancer cells shedding from the primary tumor site, thus contributing to survival and distant metastasis. However, the prognostic significance of anoikis-related genes (ARGs) and the biological functions of crucial genes in HCC have not been reported. Objectives: This study aimed to construct a model for predicting the outcome of patients with HCC based on ARGs and to investigate the clinicopathological significance and function of Rac family small GTPase 3 (RAC3) in HCC.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_04:30:57.871.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dong Wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-02 11:18:29	ID requested
⏵ 1	2025-05-07 04:30:58	announced

Publication List

Wu D, Liu ZK, Sun Y, Gou CH, Shang RZ, Lu M, Zhang RY, Wei HL, Li C, Shi Y, Zhang C, Wang YT, Wei D, Chen ZN, Bian H, Integrated Analysis of the Anoikis-Related Signature Identifies Rac Family Small GTPase 3 as a Novel Tumor-Promoter Gene in Hepatocellular Carcinoma. MedComm (2020), 6(4):e70125(2025) [pubmed]
10.1002/mco2.70125;

Wu D, Liu ZK, Sun Y, Gou CH, Shang RZ, Lu M, Zhang RY, Wei HL, Li C, Shi Y, Zhang C, Wang YT, Wei D, Chen ZN, Bian H, Integrated Analysis of the Anoikis-Related Signature Identifies Rac Family Small GTPase 3 as a Novel Tumor-Promoter Gene in Hepatocellular Carcinoma. MedComm (2020), 6(4):e70125(2025) [pubmed]

10.1002/mco2.70125;

Keyword List

submitter keyword: RAC3,HCC, anoikis

submitter keyword: RAC3,HCC, anoikis

Contact List

Huijie Bian
contact affiliation	Fourth Military Medical University
contact email	hjbian@fmmu.edu.cn
lab head
Dong Wu
contact affiliation	Fourth military medical university
contact email	1328300078@qq.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD057450
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD057450

PRIDE project URI

Repository Record List

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