PXD057427 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Critical Comparison of the Effects of Taurine, Tramiprosate, and 3-Sulfopropanoic acid on ApoE4 Aggregation |
| Description | ApoE4 is the first genetic risk factor for Alzheimer's disease. Its aberrant aggregation can be inhibited by tramiprosate (TMP) and its metabolite 3-sulfopropanoic acid (SPA), along with their impact on the transcription of genes, expression of proteins, and production of lipids. Taurine (TAU) is a close chemical analogue of TMP which has already proven beneficial effects against aging. Combining static light scattering, hydrogen-deuterium exchange mass spectrometry, molecular dynamics with analysis of Markov states, and investigation of cerebral organoids, we compare the effects of TMP, SPA, and TAU on ApoE4 aggregation, and organoid transcriptomics and proteomics. We found that TAU has a similar effect as SPA in inhibiting ApoE4 aggregation and correcting the pathophysiological phenotype of ApoE4 towards that of ApoE3 in cerebral organoids. These findings suggest that taurine may have potential as a therapeutic agent for Alzheimer's disease, particularly in individuals carrying the ApoE4/E4 genotype |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-09 |
| AnnouncementXML | Submission_2026-07-09_08:46:45.019.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Naina Verma |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Bruker Daltonics timsTOF series |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-01 05:51:36 | ID requested | |
| ⏵ 1 | 2026-07-09 08:46:45 | announced | |
| 2 | 2026-07-09 08:49:03 | announced | 2026-07-09: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: Human, mass spectrometry, Alzheimer's desease, Parkinson's disease, HDX-MS |
Contact List
| Prof. Lenka Hernychova |
|---|
| contact affiliation | RECAMO, Masaryk Memorial Cancer Institute Zluty Kopec, Brno, Czech Republic |
| contact email | lenka.hernychova@mou.cz |
| lab head | |
| Naina Verma |
|---|
| contact affiliation | Masaryk Memorial Cancer Institute |
| contact email | naina.verma@mou.cz |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057427
- Label: PRIDE project
- Name: Critical Comparison of the Effects of Taurine, Tramiprosate, and 3-Sulfopropanoic acid on ApoE4 Aggregation
