PXD057404-1

PXD057404 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	RAB GTPase proximity interactome
Description	RAB GTPases represent the most abundant family of small GTPases and regulate multiple aspects of membrane trafficking events, from cargo sorting to vesicle budding, transport, docking, and fusion. To control these processes, RABs are tightly regulated by guanine exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RABs recruit effector proteins to regulate trafficking events. Identifying RAB-associated proteins has proved difficult, as their association is often transient. Recent advances in proximity labeling approaches that allow for covalently labeling protein neighbors of proteins of interest now permit cataloging proteins in the vicinity of RAB GTPases. Here, we provide APEX2 proximity labeling on 23 human RABs and their neighboring proteomes.
HostingRepository	PRIDE
AnnounceDate	2025-12-02
AnnouncementXML	Submission_2025-12-02_08:46:03.375.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Steve Jean
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-31 09:05:00	ID requested
⏵ 1	2025-12-02 08:46:04	announced

Publication List

10.1038/s42003-025-09121-5;
Gaudreault V, Marchand B, Larcher R, Nassari S, Bourassa F, Moreau M, Jean D, Boisvert FM, Brunet MA, Jean S, A proximity map of RAB GTPases delineates roles for RAB14 in EARP complex and UHRF1BP1 endosomal recruitments. Commun Biol, 8(1):1717(2025) [pubmed]

10.1038/s42003-025-09121-5;

Gaudreault V, Marchand B, Larcher R, Nassari S, Bourassa F, Moreau M, Jean D, Boisvert FM, Brunet MA, Jean S, A proximity map of RAB GTPases delineates roles for RAB14 in EARP complex and UHRF1BP1 endosomal recruitments. Commun Biol, 8(1):1717(2025) [pubmed]

Keyword List

submitter keyword: RAB GTPase, APEX2, Membrane trafficking, BioID

submitter keyword: RAB GTPase, APEX2, Membrane trafficking, BioID

Contact List

Steve Jean
contact affiliation	Universite de Sherbrooke Departement d'immunologie et de biologie cellulaire Sherbrooke, Quebec Canada
contact email	steve.jean@usherbrooke.ca
lab head
Steve Jean
contact affiliation	Université de Sherbrooke
contact email	steve.jean@usherbrooke.ca
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD057404
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD057404

PRIDE project URI

Repository Record List

[ + ]