PXD057371-1

PXD057371 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A conserved cysteine-to-serine modification in insulin generates neoepitope-specific CD4 T-cell responses in diabetic autoimmunity
Description	We identified a T1D-relevant insulin neoantigen in which C19 of the insulin B chain is converted to serine. This neoantigen is conserved between human and mouse and is recognized by a specific, more highly activated T cell population. We demonstrated that this conversion happens at the protein level as a result of oxidative stress.
HostingRepository	MassIVE
AnnounceDate	2025-09-29
AnnouncementXML	Submission_2025-09-29_08:17:17.352.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Cheryl Lichti
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Deamidated; Oxidation; Trioxidation; Cys->Ser
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-30 14:06:45	ID requested
⏵ 1	2025-09-29 08:17:17	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: type 1 diabetes, NOD mouse, human, MHC-II peptidome, oxidative stress, crinosomes, DatasetType:Proteomics

submitter keyword: type 1 diabetes, NOD mouse, human, MHC-II peptidome, oxidative stress, crinosomes, DatasetType:Proteomics

Contact List

Xiaoxiao Wan
contact affiliation	Washington University in St. Louis
contact email	wanx@wustl.edu
lab head
Cheryl Lichti
contact affiliation	Washington University in St. Louis
contact email	clichti@wustl.edu
lab head
Cheryl Lichti
contact affiliation	Washington University in St. Louis
contact email	clichti@wustl.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096258/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096258/