PXD057298-1

PXD057298 is an original dataset announced via ProteomeXchange.

Title	Shared proteomic signature between a rat model of hypertension and Alzheimer’s disease point to cerebrovascular changes in extracellular vesicles
Description	Untreated hypertension is a risk factor for late-onset Alzheimer’s disease (AD). However, this association is not well understood, mainly due to the lack of animal models. The aim of this study was to reveal novel proteins and pathways that underlie AD associated with hypertension. Using untargeted proteomics, we analyzed brain samples from the frontal cortex of human AD (Braak stages 4-6), cerebral amyloid angiopathy (CAA), non-demented controls (Braak stages 0-3), aged (30 and 40 week-old) hypertensive rats, and age-matched normotensive Wistar Kyoto (WKY) controls. We identified 199 differentially expressed proteins (DEPs) when comparing 40-week-old SHRs to age-matched WKY control rats. Moreover, our analysis of human samples identify more than 1300 DEPs in AD when compared to control. Using a cross-species comparison, we identify 24 candidate proteins in the SHR model, whose trajectory pattern over hypertension progression align with those observed in the AD Braak staging progression. The identified candidate proteins associate significantly with the “Extracellular exosomes” pathway and are dysregulated around the cerebrovasculature in both SHR and AD brains. Our findings demonstrate cross-species translatability between AD and the SHR, and provide novel mechanistic insights into a shared dysregulation of extracellular vesicles.
HostingRepository	PRIDE
AnnounceDate	2026-02-13
AnnouncementXML	Submission_2026-02-13_05:59:15.165.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joakim Bastrup
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-29 09:18:23	ID requested
⏵ 1	2026-02-13 05:59:15	announced

10.1007/S11357-026-02097-Y;

submitter keyword: Hypertension, Alzheimer’s disease, exosomes, proteomics

Thomas Jepps
contact affiliation	University of Copenhagen, Department of Biomedical Sciences, Panum Institute 12.5, Blegdamsvej 3, Copenhagen N, Denmark.
contact email	tjepps@sund.ku.dk
lab head
Joakim Bastrup
contact affiliation	Department of Biomedical Sciences, University of Copenhagen, Denmark
contact email	joakimbastrup@hotmail.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD057298

PRIDE project URI

• PRIDE
  1. PXD057298
     1. Label: PRIDE project
     2. Name: Shared proteomic signature between a rat model of hypertension and Alzheimer’s disease point to cerebrovascular changes in extracellular vesicles