PXD057276-1

PXD057276 is an original dataset announced via ProteomeXchange.

Title	CSF prognostic markers for amyotrophic lateral sclerosis: a proteomic study
Description	The rate of disease progression widely varies between patients with amyotrophic lateral sclerosis (ALS). Prognostic assessment using biomarkers is highly preferred for planning medical care and improving the design of clinical trials. Therefore, the current study aimed to assess prognostic biomarkers for predicting future functional decline in patients with ALS. The prospective progression rate was calculated using the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) at CSF collection and in 6 months. The ALS patients were classified into slow, intermediate, and fast progression groups. We performed comprehensive proteomic analyses of the CSF samples. In total, 26 proteins changed significantly (p < 0.05 and q < 0.10), with levels varying within a large dynamic range (fold change of > 1.5 or < 0.5). A receiver operating characteristic curve analyses showed that the following proteins showed high discrimination power between slow and fast progression groups: GPNMB, GFAP, GPC1, MGAT2, and CHI3L2. Of these, GPNMB, GPC1, and CHI3L2 were significantly correlated to prognostic progression rate. This study demonstrated that CSF levels of neuroinflammation and glycosylation-related proteins were significantly correlated with prospective progression rates in patients with ALS. These proteins could be useful prognostic biomarkers for ALS.
HostingRepository	PRIDE
AnnounceDate	2024-10-31
AnnouncementXML	Submission_2024-10-31_05:11:22.923.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kimie Nakamura
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-28 21:09:23	ID requested
⏵ 1	2024-10-31 05:11:23	announced

Dataset with its publication pending

submitter keyword: cerebrospinal fluid, progression rate,amyotrophic lateral sclerosis, biomarker

Koji Fujita
contact affiliation	Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
contact email	kfujita@tokushima-u.ac.jp
lab head
Kimie Nakamura
contact affiliation	Takeda Pharmaceutical Co., Ltd.
contact email	kimie.nakamura@takeda.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD057276
     1. Label: PRIDE project
     2. Name: CSF prognostic markers for amyotrophic lateral sclerosis: a proteomic study