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PXD057275-1

PXD057275 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSeabirds in crisis: plastic ingestion induces proteomic signatures of multi-organ failure and neurodegeneration
DescriptionUnderstanding plastics’ harmful impacts has been hampered by the application of overly simplistic tools, mostly focusing on a single response variable which limits our ability to detect changes in wildlife health. Adopting a data-driven, proteomics approach, we assessed changes in 745 proteins in a non-model organism with differing levels of plastic exposure. In high plastic impacted seabirds, we observed a range of negative health consequences: intracellular components that should not be found in the blood were frequently detected, indicative of cell lysis. There was significant evidence of neurodegeneration, and secreted proteins were less abundant, indicating the kidney and particularly the liver are not functioning as normal. The proteomic signatures reflect the effects of plastic distal to the site of exposure (i.e., the stomach) demonstrating plastic shedding and leachate toxicity in the plasma. Notably, metrics commonly used to assess body condition do not provide an accurate description of health or plastic impaction.
HostingRepositoryPRIDE
AnnounceDate2025-03-27
AnnouncementXMLSubmission_2025-03-26_22:11:22.094.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRichard Wilson
SpeciesList scientific name: Fulmarus glacialis; NCBI TaxID: 30455;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-10-28 21:08:09ID requested
12025-03-26 22:11:23announced
Publication List
de Jersey AM, Lavers JL, Bond AL, Wilson R, Zosky GR, Rivers-Auty J, Seabirds in crisis: Plastic ingestion induces proteomic signatures of multiorgan failure and neurodegeneration. Sci Adv, 11(11):eads0834(2025) [pubmed]
10.1126/sciadv.ads0834;
Keyword List
submitter keyword: wildlife, proteomics,Microplastics
Contact List
Dr Richard Wilson
contact affiliationProteomics facility, Central Science Laboratory, University of Tasmania
contact emailrichard.wilson@utas.edu.au
lab head
Richard Wilson
contact affiliationUniversity of Tasmania
contact emailrichard.wilson@utas.edu.au
dataset submitter
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Dataset FTP location
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