PXD057263-1

PXD057263 is an original dataset announced via ProteomeXchange.

Title	Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis severity and progression
Description	The major proteoglycan in cartilage is COMP. This protein undergoes extensive proteolytic turnover that is believed to be dysregulated during osteoarthritis. Here we identify and describe two secreted proteases that are responsible for this turnover and identify the specific sites of proteolysis by each protease. This data was used to generate a neo-epitope antibody for validating these cleavage sites in human tissues.
HostingRepository	PRIDE
AnnounceDate	2025-02-26
AnnouncementXML	Submission_2025-02-26_11:10:40.390.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD057263
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Daniel Martin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-28 09:02:43	ID requested
⏵ 1	2025-02-26 11:10:41	announced

de Groot R, Folgado PB, Yamamoto K, Martin DR, Koch CD, Debruin D, Blagg S, Minns AF, Bhutada S, Ahnstr, ö, m J, Larkin J, Aspberg A, Ö, nnerfjord P, Apte SS, Santamaria S, Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease. Matrix Biol, 135():106-124(2025) [pubmed]

10.6019/PXD057263;

10.1016/j.matbio.2024.12.005;

submitter keyword: COMP, Proteoglycan, Osteoarthritis, ADAMTS5, ADAMTS1

Suneel Apte
contact affiliation	Cleveland Clinic, Lerner Research Institutute, Biomedical engineering, Cleveland, Ohio
contact email	aptes@ccf.org
lab head
Daniel Martin
contact affiliation	Cleveland Clinic
contact email	danmartin1008@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD057263

PRIDE project URI

• PRIDE
  1. PXD057263
     1. Label: PRIDE project
     2. Name: Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis severity and progression