PXD057247 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Human Stomach normal and gastric cancer cells LC-MSMS |
| Description | Metabolic reprogramming is a critical driver in the pathogenesis of gastric cancer (GC). However, the intricate regulatory mechanisms that govern this reprogramming and their role in GC progression remain inadequately understood. Here, we have elucidated that Methyltransferase-like 10 (METTL10) is a pivotal regulator of gastric tumorigenesis, significantly enhancing purine metabolism in GC cells. Mechanistically, METTL10 methylates and competes with the protein inhibitor of activated STAT3 (PIAS3) for binding to microphthalmia-associated transcription factor (MITF), thereby reducing the sumoylation and ubiquitination of MITF and subsequently activating purine metabolism. Moreover, the oncogenic effects of METTL10 in gastric tumorigenesis are contingent upon MITF and the methylation of lysine 442 in PIAS3, both of which are strongly correlated with poor clinical features. Additionally, we identified a compound, LZQ-02-023-01, which effectively mitigates the oncogenic activity of METTL10 in GC. These findings suggest that METTL10 is involved in purine metabolism reprogram to promote gastric cancer. These findings underscored METTL10's critical role in the metabolic reprogramming of purine metabolism and highlight its potential as a therapeutic target in the treatment of GC. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-05 |
| AnnouncementXML | Submission_2026-01-04_17:05:43.088.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Huiwen Zhou |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monomethylated residue |
| Instrument | timsTOF Pro 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-10-28 03:30:05 | ID requested | |
| ⏵ 1 | 2026-01-04 17:05:44 | announced | |
Publication List
| 10.1002/advs.202507054; |
| Tan J, Zhou H, Ma J, Zhang C, Tan Y, Zhang B, Zhao J, Cheng A, Yang C, Xu M, Zhou S, Xiong Y, Lin Z, Pan G, Ye W, Zhong M, Yang Y, Zhuang Y, Li SW, Deng X, Hong X, METTL10-Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression. Adv Sci (Weinh), 12(48):e07054(2025) [pubmed] |
Keyword List
| submitter keyword: Human, LC-MSMS, Stomach |
Contact List
| xuehui hong |
|---|
| contact affiliation | Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen |
| contact email | hongxu@xmu.edu.cn |
| lab head | |
| Huiwen Zhou |
|---|
| contact affiliation | Xiamen University |
| contact email | zhwdoctorwen@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD057247 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057247
- Label: PRIDE project
- Name: Human Stomach normal and gastric cancer cells LC-MSMS
