PXD057210-1

PXD057210 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Immunoglobulins G from Systemic Sclerosis Patients Modify the Molecular Signatures of Endothelial Cells
Description	Systemic sclerosis (SSc) is a heterogeneous connective tissue disease characterized by autoimmunity, vasculopathy and excessive fibrosis. Antinuclear antibodies (ANA) are strong diagnostic and prognosis biomarkers but their pathogenicity in fibrosis and vasculopathy remains unclear. Functional antibodies (FA) have been described and might be implicated in the vasculopathy of SSc, in which endothelial cells (EC) are key players. We aimed to explore the effect of purified IgG from SSc patients on omics signature of EC and examine the influence of ANA serotypes or FA.
HostingRepository	PRIDE
AnnounceDate	2025-03-24
AnnouncementXML	Submission_2025-03-24_10:23:04.522.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	BRAY FABRICE
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-25 12:01:38	ID requested
⏵ 1	2025-03-24 10:23:04	announced

Publication List

10.1136/RMDOPEN-2024-004290;

10.1136/RMDOPEN-2024-004290;

Keyword List

submitter keyword: Endothelial Cells, Systemic Sclerosis, AQUA peptides,IgG, Proteomics, Antinuclear antibodies

submitter keyword: Endothelial Cells, Systemic Sclerosis, AQUA peptides,IgG, Proteomics, Antinuclear antibodies

Contact List

fabrice bray
contact affiliation	Laboratoire MSAP UAR 3290 CNRS Bâtiment C4 Avenue Paul Langevin Cité Scientifique 59655 Villeneuve D'ascq 03 20 33 71 12 https://msap-lab.fr/
contact email	fabriice.bray@univ-lille.fr
lab head
BRAY FABRICE
contact affiliation	MSAP USR 3290
contact email	fabrice.bray@univ-lille.fr
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD057210
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD057210

PRIDE project URI

Repository Record List

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