PXD057161 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The quantitative proteomics analysis of TGF-β induced EMT in A549 cells and TNS-overexpressing A549 cells |
| Description | Metastasis is the primary cause of mortality in lung cancer patients, with the epithelial-mesenchymal transition (EMT) process conferring increased metastatic potential to carcinoma cells. While emerging evidence suggests that TNS1 contributes to carcinoma metastasis, it remains unclear the role of TNS1 in EMT. In this study, we reveal TNS1 as an indispensable factor in TGF-β and hypoxia mediated EMT process. Elevated TNS1 protein levels are closely correlated with a worse prognosis in lung cancer patients. TNS1 is also found to potently promote EMT process and tumor metastasis in vitro and in vivo. Mechanistically, TNS1 expression is mediated by the transcription factor SMAD3 in TGF-β signaling. Moreover, TNS1 interacts with and modulates ZEB1 expression, preventing ZEB1 ubiquitination degradation. Therefore, our study reveals the role of TNS1 in the EMT process and suggests that TNS1 promises to a candidate for targeted cancer therapy. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-08 |
| AnnouncementXML | Submission_2025-12-07_16:32:47.490.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tingting Zhang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-10-24 12:21:59 | ID requested | |
| ⏵ 1 | 2025-12-07 16:32:48 | announced | |
Publication List
| Zhang T, Li Z, Ming Y, Li J, Ye Z, Luo D, Wang R, Yang Y, Yang X, Peng Y, -induced epithelial-to-mesenchymal transition in lung cancer. Commun Biol, 8(1):1686(2025) [pubmed] |
| 10.1038/s42003-025-09079-4; |
Keyword List
| submitter keyword: Epithelial-mesenchymal transition (EMT), TNS1,Lung cancer, SMAD3, ZEB1 |
Contact List
| Yong Peng |
|---|
| contact affiliation | Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Scienc Center for Disease-Related Molecular Network, West China Hospital |
| contact email | ttcpu2012@126.com |
| lab head | |
| Tingting Zhang |
|---|
| contact affiliation | Key Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China |
| contact email | ttcpu2012@126.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD057161 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057161
- Label: PRIDE project
- Name: The quantitative proteomics analysis of TGF-β induced EMT in A549 cells and TNS-overexpressing A549 cells
