PXD057160-1

PXD057160 is an original dataset announced via ProteomeXchange.

Title	A High-salt diet induces immune-independent re-differentiation of melanoma, metabolic shut down and cell-cycle arrest
Description	A high salt diet (HSD) is known to reduce cancer growth in some models, due to accumulation of sodium in the skin, which enhanced local anti-tumor immunity. Here we show that a HSD inhibits melanoma growth in both skin and lung, independent from sodium accumulation and from immune cells. Melanoma cells from mice on a HSD upregulated the metabolic inhibitor Tuberous sclerosis complex 2 (TSC2), causing metabolic shutdown, despite nutrient availability. Furthermore, Microphthalmia-associated transcription factor (MITF), a crucial regulator of melanoma metabolism and differentiation, was upregulated, resulting in enhanced melanogenesis and cell cycle arrest. Thus, a HSD reversed the dedifferentiation of melanoma tumor cells and promoted their re-differentiation into a “normal”, melanocytic state. These findings suggest the anti-tumor effects of a HSD may be tumor specific and in some cases immune-independent.
HostingRepository	PRIDE
AnnounceDate	2026-01-02
AnnouncementXML	Submission_2026-01-02_03:01:06.943.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christian Münch
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-24 11:34:54	ID requested
⏵ 1	2026-01-02 03:01:08	announced

10.1038/s41419-025-08329-x;

Lisowski C, Stumpf NE, Jobin K, Klaus D, Eichler M, Baumgart AK, Babyak O, Mei, ß, ner M, Schr, ö, der A, Neubert P, Schmitt V, Michla M, Bozkurt S, Zurkovic J, Hinze D, Liebing J, Eckhardt M, Heuser C, Seep L, Heine A, Becker-Gotot J, Thiele C, M, ü, nch C, Becker T, Jantsch J, Wilhelm C, H, ö, lzel M, Kurts C, High-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma. Cell Death Dis, 17(1):102(2025) [pubmed]

submitter keyword: melanogenesis, TMTpro, mouse, LC-MS3, melanoma,high salt diet

Christian Münch
contact affiliation	Institute of Molecular Systems Medicine, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany. The Center for Functional Proteomics, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany. Frankfurt Cancer Institute, Frankfurt am Main, Germany. Cardio-Pulmonary Institute, Frankfurt am Main, Germany.
contact email	bozkurt@med.uni-frankfurt.de
lab head
Christian Münch
contact affiliation	Goethe University Frankfurt
contact email	ch.muench@em.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD057160

PRIDE project URI

• PRIDE
  1. PXD057160
     1. Label: PRIDE project
     2. Name: A High-salt diet induces immune-independent re-differentiation of melanoma, metabolic shut down and cell-cycle arrest