PXD057150-1

PXD057150 is an original dataset announced via ProteomeXchange.

Title	Histone PTM profiling in breast cancer clinical samples
Description	Although cancer was long considered a genetic disease, the contribution of epigenetics to various aspects of cancer biology is now being increasingly recognized. In particular, aberrations in the deposition and maintenance of histone post-translational modifications (PTMs) can result in the inappropriate expression or silencing of genes, potentially leading to cancer. Here, we applied quantitative mass-spectrometry-based technologies to study histone PTMs and variants in different breast cancer subtypes, with a special focus on triple-negative breast cancers (TNBCs), which comprise a heterogeneous group of tumors lacking well-defined molecular targets and targeted therapies.
HostingRepository	PRIDE
AnnounceDate	2025-08-01
AnnouncementXML	Submission_2025-08-01_08:45:41.050.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roberta Noberini
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monomethylated residue; N6; acetylated residue; dimethylated residue
Instrument	Q Exactive HF; Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-24 05:24:32	ID requested
⏵ 1	2025-08-01 08:45:41	announced

Dataset with its publication pending

submitter keyword: breast cancer,histone post-translational modifications, epigenetics

Tiziana Bonaldi
contact affiliation	European Institute of Oncology, Milan, Italy
contact email	tiziana.bonaldi@ieo.it
lab head
Roberta Noberini
contact affiliation	Istituto Europeo di Oncologia
contact email	roberta.noberini@ieo.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD057150

PRIDE project URI

• PRIDE
  1. PXD057150
     1. Label: PRIDE project
     2. Name: Histone PTM profiling in breast cancer clinical samples