PXD057069 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Muscle Cathepsin B benefits Alzheimer's Disease mice |
| Description | Muscle secretes factors during exercise that enhance cognition. Myokine Cathepsin B (Ctsb) is linked to memory, but its role in neurodegeneration is unclear. Here we show that AAV-vector-mediated Ctsb overexpression in skeletal muscle, in an Alzheimer’s Disease (AD) mouse model (APP/PS1), improved motor coordination, memory and adult hippocampal neurogenesis, while plaque density was unchanged. Conversely, in wildtype (WT) mice Ctsb impaired memory. To understand underlying mechanisms, hippocampus, muscle and plasma proteomic analyses were performed. In AD mice, Ctsb treatment increased abundance of hippocampal proteins involved in mRNA metabolism and protein synthesis. In muscle, Ctsb treatment increased protein translation in AD mice, whereas in WT mitochondrial proteins decreased. Additionally, in AD mice Ctsb enhanced plasma metabolic and mitochondrial processes, and reduced inflammatory responses. The differing protein abundance profiles in the AD and WT treatment groups correspond to effects on memory function. Overall, skeletal muscle Ctsb expression is a potential AD therapeutic. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-17 |
| AnnouncementXML | Submission_2025-11-16_20:03:54.986.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hazal Haytural |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-10-22 14:33:13 | ID requested | |
| ⏵ 1 | 2025-11-16 20:03:56 | announced | |
Publication List
| 10.1111/acel.70242; |
| Pinto A, Haytural H, Loss CM, Alvarez C, Ertas A, Curtis O, Williams AR, Murphy G, Salleng KJ, Gografe S, Visavadiya NP, Khamoui AV, Alt, ı, nta, ş A, Kafri T, Barres R, Deshmukh AS, van Praag H, Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease. Aging Cell, 24(11):e70242(2025) [pubmed] |
Keyword List
| submitter keyword: organ cross-talk, proteomics, Alzheimer's disease,Cathepsin B |
Contact List
| Atul Deshmukh |
|---|
| contact affiliation | University of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic Research, Denmark |
| contact email | atul.deshmukh@sund.ku.dk |
| lab head | |
| Hazal Haytural |
|---|
| contact affiliation | University of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic Research |
| contact email | hazal.haytural@sund.ku.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057069
- Label: PRIDE project
- Name: Muscle Cathepsin B benefits Alzheimer's Disease mice
