PXD056997-1

PXD056997 is an original dataset announced via ProteomeXchange.

Title	Identification of acetylation sites of TRPV4 protein in mouse liver
Description	Prenatal development may adopt unique patterns of metabolic responses to different nutrient supplies. AMPK and mTOR are two central metabolic regulators, with AMPK acting to slow down and mTOR to promote anabolism. Here, we observed surprisingly that mTORC1 in the foetal liver remains active in low glucose, although AMPK is effectively activated in an AMP-dependent manner. Mechanistically, we found that TRPV4, one main member of TRPVs in the liver, is acetylated, disabling its inactivation by FBP-unoccupied aldolase. It suggested that the TRPV-mediated resistance of mTORC1 inhibition in low glucose for normal foetal development.
HostingRepository	iProX
AnnounceDate	2024-10-21
AnnouncementXML	Submission_2024-10-21_00:07:37.088.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chuanjin Yu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	acetylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-21 00:07:17	ID requested
⏵ 1	2024-10-21 00:07:37	announced

Dataset with its publication pending

submitter keyword: mTOR, Mouse liver, TRPV4 protein acetylation

Hefeng Huang
contact affiliation	Zhejiang University School of Medicine
contact email	huanghefg@hotmail.com
lab head
Chuanjin Yu
contact affiliation	Institute of Reproduction and Development, Fudan University
contact email	yuchuanjin1013@163.com
dataset submitter

iProX dataset URI