PXD056932-1

PXD056932 is an original dataset announced via ProteomeXchange.

Title	Impact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic Stress Model
Description	Chronic stress is a common cause of hair loss, involving inflammatory responses and changes in cellular signaling pathways. This study explores the mechanism of action of the SDF-1/CXCR4 signaling axis in chronic stress-induced hair loss. The research indicates that SDF-1 promotes hair follicle growth through the PI3K/Akt and JAK/STAT signaling pathways. Transcriptome sequencing analysis was conducted to identify differentially expressed genes in the skin of normal and stressed mice, with key genes SDF-1/CXCR4 selected through machine learning and a protein-protein interaction network established. A chronic stress mouse model was created, with injections of SDF-1 and AMD3100 administered to observe hair growth, weight changes, and behavioral alterations and validate hair follicle activity
HostingRepository	iProX
AnnounceDate	2024-10-18
AnnouncementXML	Submission_2024-12-25_19:10:54.163.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hong Li
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-17 23:51:49	ID requested
⏵ 1	2024-12-25 19:10:55	announced

Zhao Y, Liang W, Liu Z, Chen X, Lin C, Impact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic Stress Model. Biomolecules, 14(10):(2024) [pubmed]

submitter keyword: Chronic Stress

Changmin Lin
contact affiliation	Department of Histology and Embryology
contact email	lin@stu.edu.cn
lab head
Hong Li
contact affiliation	The First Affiliated Hospital ,Jiangxi Medical College of Nanchang University
contact email	1545559471@qq.com
dataset submitter

iProX dataset URI