PXD056923-1

PXD056923 is an original dataset announced via ProteomeXchange.

Title	Extracellular vesicle-derived VDAC1 protein promotes paclitaxel resistance through autophagy and mitophagy in gastric cancer
Description	Gastric cancer (GC) is ranked as as the third most prevalent malignant tumor worldwide [1, 2]. Chemotherapy is considered the primary therapeutic approach for metastatic and unresectable GC [3]. Paclitaxel (PTX) is an anti-microtubule agent, and single therapy with PTX or PTX-based chemotherapy combined with other chemotherapy has demonstrated promising efficacy in clinical treatment in patients with advanced GC [4]. However, PTX-based chemotherapy is limited by acquired chemoresistance[5]. Mounting evidence have indicated that drug resistance in cancer cells is a major contributing factor for the failure of tumor treatment,resulting in the rapid recurrence, progression, and ultimately, patient mortality [6]. GC exhibits higher tissue heterogeneity and invasive behavior compared to other primary tumors [7]. Therefore, it is essential to promptly uncover the mechanisms underlying drug resistance in GC and meet unmet needs in GC treatment.
HostingRepository	iProX
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_20:19:32.714.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanan Bi
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-17 20:18:59	ID requested
⏵ 1	2024-10-17 20:19:33	announced

Dataset with its publication pending

submitter keyword: Gastric Cancer, Paclitaxel-resistance, Extracellular vesicles, VDAC1, Autophagy, Mitophagy

Lianmei Zhao
contact affiliation	the Fourth Hospital of Hebei University
contact email	lianmei555@hebmu.edu.cn
lab head
Yanan Bi
contact affiliation	the Fourth Hospital of Hebei University
contact email	2421918544@qq.com
dataset submitter

iProX dataset URI