PXD056923-1
PXD056923 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Extracellular vesicle-derived VDAC1 protein promotes paclitaxel resistance through autophagy and mitophagy in gastric cancer |
Description | Gastric cancer (GC) is ranked as as the third most prevalent malignant tumor worldwide [1, 2]. Chemotherapy is considered the primary therapeutic approach for metastatic and unresectable GC [3]. Paclitaxel (PTX) is an anti-microtubule agent, and single therapy with PTX or PTX-based chemotherapy combined with other chemotherapy has demonstrated promising efficacy in clinical treatment in patients with advanced GC [4]. However, PTX-based chemotherapy is limited by acquired chemoresistance[5]. Mounting evidence have indicated that drug resistance in cancer cells is a major contributing factor for the failure of tumor treatment,resulting in the rapid recurrence, progression, and ultimately, patient mortality [6]. GC exhibits higher tissue heterogeneity and invasive behavior compared to other primary tumors [7]. Therefore, it is essential to promptly uncover the mechanisms underlying drug resistance in GC and meet unmet needs in GC treatment. |
HostingRepository | iProX |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_20:19:32.714.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yanan Bi |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-10-17 20:18:59 | ID requested | |
⏵ 1 | 2024-10-17 20:19:33 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Gastric Cancer, Paclitaxel-resistance, Extracellular vesicles, VDAC1, Autophagy, Mitophagy |
Contact List
Lianmei Zhao | |
---|---|
contact affiliation | the Fourth Hospital of Hebei University |
contact email | lianmei555@hebmu.edu.cn |
lab head | |
Yanan Bi | |
contact affiliation | the Fourth Hospital of Hebei University |
contact email | 2421918544@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |