PXD056899-1

PXD056899 is an original dataset announced via ProteomeXchange.

Title	human MS Lesions ABPP - foamy microglia link oxylipins to disease progression in multiple sclerosis
Description	In this study lesions from human MS brains and controls were isolated and analyzed by Activity-based protein profiling using fluorophosphonate- and beta-lacton probes to enrich active enzymes from the samples. these were subsequently analyzed by LC/MS-MS.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-06_17:27:52.799.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daan Van der Vliet
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-17 04:51:06	ID requested
⏵ 1	2026-09-06 17:27:53	announced

van der Vliet D, Di X, Shamorkina TM, Coulon-Bainier C, Pavlovic A, van der Vliet IACM, Zeng Y, Macnair W, van Egmond N, Chen JQA, van den Bosch AMR, Engelenburg HJ, Wever D, Mason MRJ, Driever WPF, Gagestein B, Dusseldorp E, van Eijk M, Grether U, Harms AC, Hankemeier T, Collin L, Heck AJR, Huitinga I, van der Stelt M, van den Bosch AMR, de Goeij M, Rozemuller AJM, Foamy microglia link oxylipins to disease progression in multiple sclerosis. Nat Neurosci, 29(7):1585-1598(2026) [pubmed]

10.1038/s41593-026-02302-3;

submitter keyword: Multiple Sclerosis, Activity-based protein profiling, serine hydrolase, lesions, brain, chemical proteomics, fluorophosphonate

Mario van der Stelt
contact affiliation	Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
contact email	m.van.der.stelt@chem.leidenuniv.nl
lab head
Daan Van der Vliet
contact affiliation	Leiden University
contact email	d.van.der.vliet@lic.leidenuniv.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD056899

PRIDE project URI

• PRIDE
  1. PXD056899
     1. Label: PRIDE project
     2. Name: human MS Lesions ABPP - foamy microglia link oxylipins to disease progression in multiple sclerosis