PXD056848 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer |
| Description | To understand the transcriptomic, genomic and proteomics changes between HER2 overexpressingcells and those that have become resistant to lapatinib |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-17 |
| AnnouncementXML | Submission_2025-11-16_16:17:21.082.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD056848 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Vinothini Rajeeve |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | amidated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-10-16 03:21:55 | ID requested | |
| ⏵ 1 | 2025-11-16 16:17:22 | announced | |
Publication List
| 10.1038/s41416-025-03174-3; |
| 10.6019/PXD056848; |
| Steggall J, Rajeeve V, Al-Subaie N, Naeem A, Ikram A, Naeem A, Hayat A, Integrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer. Br J Cancer, 133(10):1471-1482(2025) [pubmed] |
Keyword List
| submitter keyword: 3D,Chromatin, proteomics, epigenetics, resistance, HER2, LC-MS/MS |
Contact List
| Professor Pedro Cutillas |
|---|
| contact affiliation | Mass Spectrometry Facility Barts Cancer Institute, Queen Mary,University of LondonRoom 1.02-1.03, 1st Floor, John Vane Science Centre Charterhouse Square London EC1M 6BQ |
| contact email | p.cutillas@qmul.ac.uk |
| lab head | |
| Vinothini Rajeeve |
|---|
| contact affiliation | Centre for Haemato Oncology |
| contact email | v.rajeeve@qmul.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD056848 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD056848
- Label: PRIDE project
- Name: Integrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer
