PXD056800-1
PXD056800 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrative Proteome and Lysine Acetylation Analyses of Subcutaneous and Visceral Adipose Tissues in People with Metabolically Unhealthy Obesity |
| Description | Adipose tissue is critical in the development of Metabolically unhealthy obesity (MUO). This study aimed to investigate the different responses and regulations of subcutaneous (SA) and visceral adipose tissue (VA) to MUO by integrative proteome and lysine acetylation (Kac) analyses. This study significantly expanded the known set of proteins and acetylated proteins by reporting the differential expression and Kac modifications in VA and SA in MUO for the first time, thereby establishing a foundation for exploring the pathogenesis and treatment of MUO. |
| HostingRepository | iProX |
| AnnounceDate | 2024-10-15 |
| AnnouncementXML | Submission_2025-09-03_00:25:48.221.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiyi Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-14 20:29:35 | ID requested | |
| ⏵ 1 | 2025-09-03 00:25:50 | announced |
Publication List
| Guo H, Zhang Z, Yang J, Liu J, Lin H, Yin N, Depot-specific acetylation profiles of adipose tissues-therapeutic targets for metabolically unhealthy obesity. Diabetol Metab Syndr, 17(1):36(2025) [pubmed] |
Keyword List
| submitter keyword: Proteome, Lysine acetylation, Obesity, Metabolic syndrome, Metabolically unhealthy obesity, Adipose tissue |
Contact List
| Juntao Yang | |
|---|---|
| contact affiliation | Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China |
| contact email | yangjt@pumc.edu.cn |
| lab head | |
| Zhiyi Zhang | |
| contact affiliation | Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China |
| contact email | zyzhang@pumc.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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