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PXD056790-2

PXD056790 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRemodeling of the neutrophil proteome upon exposure to Pseudomonas aeruginosa biofilms
DescriptionNeutrophils are the most prominent cell in the immune system, accounting for 70% of circulating leukocytes, and acting as the first line of defense against various invading pathogens. For example, neutrophils engage in phagocytosis, degranulation, and neutrophil extracellular trap formation to respond to pathogens. Pseudomonas aeruginosa is a Gram-negative bacterium that readily forms biofilms (i.e., high-density bacterial clusters attached to surfaces) to provide protection from the host immune system, antibiotic treatment, and antimicrobial agents. Neutrophils are essential to clear P. aeruginosa biofilms and infections through the actions of antimicrobial proteins and peptides. In this study, we evaluated proteome remodeling of the host following exposure of neutrophils (differentiated from HL-60 cells) to P. aeruginosa biofilms.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_07:01:58.130.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJennifer Geddes-McAlister
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Pseudomonas aeruginosa PAO1; NCBI TaxID: 208964;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 240
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-10-14 09:45:05ID requested
12024-10-14 12:22:06announced
22024-10-22 07:01:58announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: neutrophils,Total proteome, Pseudomonas aeruginosa, biofilms
Contact List
Dr. Jennifer Geddes-McAlister
contact affiliationMolecular and Cellular Biology Department, University of Guelph, Guelph, ON, Canada
contact emailjgeddesm@uoguelph.ca
lab head
Jennifer Geddes-McAlister
contact affiliationUniversity of Guelph
contact emailjgeddesm@uoguelph.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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