PXD056780-1
PXD056780 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | THE AGING SYNAPSE: AN INTEGRATED PROTEOMIC AND TRANSCRIPTOMIC ANALYSIS. |
| Description | An important hallmark of aging is the loss of proteostasis, which can lead to the formation of protein aggregates and mitochondrial dysfunction in neurons. Although it is well known that protein synthesis is finely regulated in the brain, especially at synapses, where mRNAs are locally translated in activity-dependent manner, little is known as to the changes in the synaptic proteome and transcriptome during aging. Therefore, this work aims to elucidate the relationship between transcriptome and proteome at soma and synaptic level during aging. Proteomic and transcriptomic data analysis reveal that, in young animals, proteins and transcripts are correlated and synaptic regulation is driven by changes in the soma. During aging, there is a decoupling between transcripts and proteins and between somatic and synaptic compartments. Furthermore, soma-synapse gradient of ribosomal genes changes upon aging, i.e. ribosomal transcripts are less abundant and ribosomal proteins are more abundant in synaptic compartment of old mice with respect to younglings. Additionally, transcriptomics data highlight a difference in the splicing of certain synaptic mRNA with aging. Taken together, our data provide a valuable resource for the study of the aging synapse. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-10-06 |
| AnnouncementXML | Submission_2025-10-06_00:35:26.983.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Leibniz FLI Proteomics |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Carbamidomethyl; Acetyl; Oxidation |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-14 04:59:19 | ID requested | |
| ⏵ 1 | 2025-10-06 00:35:27 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: RNA-Seq, Synaptosomes, Alternative Splicing, Bioinformatics, Aging, DatasetType:Proteomics |
Contact List
| Alessandro Cellerino | |
|---|---|
| contact affiliation | Leibniz Institute on Aging, Beutenbergstr. 11, 07745 Jena |
| contact email | Alessandro.Cellerino@leibniz-fli.de |
| lab head | |
| Leibniz FLI Proteomics | |
| contact affiliation | Leibniz FLI |
| contact email | proteomics@leibniz-fli.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000096075/ |
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