PXD056769-1

PXD056769 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling reveals the impact of surface functionalization on the protein corona formed on superparamagnetic iron oxide nanoparticles
Description	The protein corona formed on the surface of nanomaterials is critical to understanding their biological behavior, as it is regulated by both the physicochemical properties of the nanomaterials and the physiological environment. The interplay between material synthesis characteristics, protein corona composition, and biological fate remains to be fully elucidated. In this project, we investigated the protein corona of six types of 30 nm superparamagnetic iron oxide nanoparticles (IONPs), each coated with dextran and modified with different functional groups (hydroxyl, amine, and carboxyl). Proteomic analysis revealed that nanoparticles with the same surface modifications had similar protein corona compositions, while those with different surface modifications exhibited distinct complement protein profiles. These findings provide a theoretical basis for understanding the immunological responses induced by each nanoparticle type, offering insights into their biological and therapeutic applications.
HostingRepository	iProX
AnnounceDate	2024-10-14
AnnouncementXML	Submission_2025-08-21_20:09:39.433.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qihui Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-13 21:15:52	ID requested
⏵ 1	2025-08-21 20:09:40	announced

Li Y, Wu W, Liu Q, Wu Q, Ren P, Xi X, Liu H, Zhao J, Zhang W, Wang Z, Lv Y, Tian B, Sun S, Cui J, Zhao Y, Wu J, Gao M, Chen F, Specific surface-modified iron oxide nanoparticles trigger complement-dependent innate and adaptive antileukaemia immunity. Nat Commun, 15(1):10400(2024) [pubmed]

submitter keyword: iron oxide nanoparticles, protein corona, LC-MS

Fangfang Chen
contact affiliation	China-Japan Union Hospital of Jilin University
contact email	cff@jlu.edu.cn
lab head
Qihui Liu
contact affiliation	China-Japan Union Hospital of Jilin University
contact email	liuqihui@jlu.edu.cn
dataset submitter

iProX dataset URI