PXD056717-1

PXD056717 is an original dataset announced via ProteomeXchange.

Title	Loss of GABAergic D-type motor neurons in young adult Caenorhabditis elegans after exposition with silica nanoparticles
Description	Although C. elegans is commonly used to assess the neurotoxicity of environmental pollutants, studies that explore the intricate biology of its nervous system, particularly those addressing long term effects and aging in adult worms, are rare. These models offer significant advantages for understanding the full spectrum of neurobiological impacts. Here, we investigated the effects of silica nanomaterials on the GABAergic neural system in young to middle-aged nematodes. Results showed a novel degeneration pattern characterized by loss of anterior- and posteriormost GABAergic D-type motor neurons. Proteomics of 4-day-old C. elegans revealed significant alterations of protein abundance including the downregulation of proteins such as glutamate dehydrogenase (gdh-1), and glutamate oxaloacetate transaminase (got-1.2) which are essentially involved in GABA metabolic pathways.
HostingRepository	PRIDE
AnnounceDate	2025-03-25
AnnouncementXML	Submission_2025-03-25_13:35:07.715.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gereon Poschmann
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-11 01:53:45	ID requested
⏵ 1	2025-03-25 13:35:08	announced

10.3390/cells14030190;

Le DT, Pauls S, Poschmann G, St, ü, hler K, von Mikecz A, Following Exposition with Silica Nanoparticles. Cells, 14(3):(2025) [pubmed]

submitter keyword: nanoscale silica, C. elegans, neurodegeneration, environmental pollutants, GABAergic D-type motor neurons

Gereon Poschmann
contact affiliation	Proteome Research (AG Stühler) Institute of Molecular Medicine Heinrich Heine University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany
contact email	gereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliation	Molecular Proteomics Laboratory
contact email	gereon.poschmann@hhu.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD056717
     1. Label: PRIDE project
     2. Name: Loss of GABAergic D-type motor neurons in young adult Caenorhabditis elegans after exposition with silica nanoparticles